{"id":4927,"date":"2025-03-05T16:17:04","date_gmt":"2025-03-05T19:17:04","guid":{"rendered":"https:\/\/test.uandes.cl\/?p=4927"},"modified":"2025-04-09T12:46:59","modified_gmt":"2025-04-09T15:46:59","slug":"chilean-scientists-lead-groundbreaking-osteoarthritis-research-first-patient-in-the-world-to-present-lasting-pain-relief-and-improved-mobility","status":"publish","type":"post","link":"https:\/\/investiga.uandes.cl\/en\/chilean-scientists-lead-groundbreaking-osteoarthritis-research-first-patient-in-the-world-to-present-lasting-pain-relief-and-improved-mobility\/","title":{"rendered":"Chilean scientists lead research in osteoarthritis: world's first patient presented lasting pain relief and improved mobility"},"content":{"rendered":"

Jos\u00e9 Matas, traumatologist at Cl\u00ednica Universidad de los Andes\u00a0<\/strong>, who was in charge of administering the treatment to the patient, explained that the improvements presented after the treatment were related to a considerable decrease in pain and an increase in the mobility and function of the joint. \"It is impossible to compare this therapy with the usual treatments for osteoarthrosis of the knee, since it was only one patient. However, advanced acellular therapies in the treatment of osteoarthrosis generate a lot of expectation of improvement in the medical community.\"<\/p>\n\n\n\n

A 56-year-old Chilean woman with osteoarthritis of the knee and constant pain became the first patient in the world to receive a dose of intra-articular therapy based on small extracellular vesicles enriched with exosomes, presenting a remarkable and long-lasting improvement. <\/strong>The results, which were described as promising, were published by the scientific journal <\/a>Journal of Nanobiotechnology<\/mark><\/span><\/strong><\/a>on January 13th, 2025.<\/p>\n\n\n\n

Extracellular vesicles are nanoparticles secreted by cells and fulfill various functions ranging from intercellular communication to modulation of the immune response. Among the extracellular vesicles are exosomes, which also contribute to cellular communication, but stand out for their role in tissue repair in the human body.<\/p>\n\n\n\n

Researchers from the IMPACT center, in collaboration with the start-up EVast Bio<\/a> , oriented to the development of extracellular vesicles, lead this study <\/strong>to deepen the therapeutic use of these vesicles in knee osteoarthritis, achieving the milestone of being the first patient in the world to receive such a therapy for this disease.<\/strong><\/p>\n\n\n

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\"\"<\/figure>\n<\/div>\n\n\n

<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

For Francisca Alcagaya, principal investigator of IMPACT, <\/strong>this research represents an important advance in the field of regenerative therapies: \"This is the first time that extracellular vesicles derived from umbilical cord stromal cells have been shown to be used as a safe treatment for osteoarthritis of the knee. What is relevant is that they not only help to reduce inflammation, but also protect cartilage, opening the door to less invasive and more effective treatments for joint diseases. The results in this patient are very promising. She was able to significantly relieve pain, improve her mobility and prevent further deterioration of the joint, with effects that were sustained for one year. This suggests that this therapy could become a real alternative to options such as traditional infiltrations or even surgery, offering longer-lasting and less invasive benefits,\" she said.<\/p>\n\n\n\n

When asked about the future of advanced therapies in the treatment of osteoarthritis, the expert pointed out that, in her opinion, the future of these therapies is very promising. \"Advances such as the use of extracellular vesicles bring us closer to treatments that not only alleviate symptoms, but also have the potential to regenerate damaged tissue and modify the course of diseases such as osteoarthritis. If we continue to move in this direction, we could transform the way these pathologies are managed.\"<\/strong><\/p>\n\n\n\n

Aliosha I. Figueroa-Vald\u00e9s<\/a>,
Patricia Luz-Crawford<\/a>,
Yeimi Herrera-Luna<\/a>,
Nicolas Georges-Calderon<\/a>,
Cynthia Garcia<\/a>,
Hugo E. Tobar<\/a>,
Mar\u00eda Jes\u00fas Araya<\/a>,
Jos\u00e9 Matas<\/a>,
Dar\u00edo Donoso-Meneses<\/a>,
Catalina de la Fuente<\/a>,
Jimena Cuenca<\/a>,
Eliseo Parra<\/a>,
Fernando Lillo<\/a>,
Crist\u00f3bal Varela<\/a>,
Mar\u00eda Ignacia C\u00e1diz<\/a>,
Rolando Vernal<\/a>,
Alexander Ortloff<\/a>,
Gino Nardocci<\/a>,
Ver\u00f3nica Casta\u00f1eda<\/a>,
Catalina Adasme-Vidal<\/a>,
Maximilian Kunze-K\u00fcllmer<\/a>,
Yessia Hidalgo<\/a>,
Francisco Espinoza<\/a>,
Maroun Khoury<\/a> &
Francisca Alcayaga-Miranda<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\"\"<\/figure>","protected":false},"excerpt":{"rendered":"

Jos\u00e9 Matas, a traumatologist at Cl\u00ednica Universidad de los Andes, was in charge of administering the treatment.<\/p>","protected":false},"author":2,"featured_media":5426,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[3],"tags":[44],"class_list":["post-4927","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud","tag-44"],"yoast_head":"\nCient\u00edficos chilenos lideran investigaci\u00f3n en osteoartritis: primera paciente en el mundo present\u00f3 alivio duradero del dolor y mejor movilidad - Investiga UANDES<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/investiga.uandes.cl\/en\/chilean-scientists-lead-groundbreaking-osteoarthritis-research-first-patient-in-the-world-to-present-lasting-pain-relief-and-improved-mobility\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cient\u00edficos chilenos lideran investigaci\u00f3n en osteoartritis: primera paciente en el mundo present\u00f3 alivio duradero del dolor y mejor movilidad - 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