{"id":1284,"date":"2025-02-05T00:00:00","date_gmt":"2025-02-05T03:00:00","guid":{"rendered":"http:\/\/envirra.com\/themes\/sprout2\/2020\/12\/30\/five-solid-evidences-why-photography-is-bad-for-your-career-development\/"},"modified":"2025-11-26T18:58:04","modified_gmt":"2025-11-26T21:58:04","slug":"in-search-of-the-international-seal","status":"publish","type":"post","link":"https:\/\/investiga.uandes.cl\/en\/in-search-of-the-international-seal\/","title":{"rendered":"Chilean researchers develop new test to diagnose hypertension in young Chileans"},"content":{"rendered":"

A team led by scientist Maroun Khoury, Director of the IMPACT Center of Excellence <\/strong><\/a>, which includes leading scientists from important research centers such as Millennium Institute in Engineering and Artificial Intelligence for Health (i-HEALTH)<\/strong><\/a>, the Institute of Biological and Medical Engineering of Pontificia Universidad Cat\u00f3lica<\/strong><\/a>, the Center for Biomedical Research and Innovation of Universidad de los Andes<\/strong><\/a>, the Advanced Mining Technology Center of University of Chile<\/a>, and the Science and Technology Research Ring 2021 project for the production of biopharmaceuticals at Pontificia Universidad Cat\u00f3lica de Valpara\u00edso<\/a> , found that the transfer of mitochondria (the energy-producing organelles of cells) from mesenchymal stem cells to T cells can significantly increase their survival rates and their ability to fight cancer.<\/strong><\/p>\n\n\n\n

The study, published in the scientific journal, Journal of Translational Medicine,<\/strong><\/a>was conducted in collaboration with Brazil's National Cancer Institute (INCA), highlights how this innovative mitochondrial transfer technique can enhance natural and engineered T cells, paving the way for advances in cancer immunotherapy.<\/p>\n\n\n\n

This research was conducted in the IMPACT Basal Center<\/a><\/strong>, which is financed by the Chilean National Agency for Research and Development (ANID)<\/a><\/strong> , develops and implements technologies that allow access in Chile to the most successful advanced medical therapies in the world.<\/strong>IMPACT also supports the creation of a network, both in Santiago and in the regions, to accelerate multidisciplinary research with high translational impact.<\/p>\n\n\n\n

<\/p>\n\n\n\n

\"From
From left to right: Fernando Figueroa; Juan Pablo Acevedo; Francisca Alcayaga and Maroun Khoury.<\/figcaption><\/figure>\n\n\n\n

This discovery has implemented an innovative method to enhance T and CAR-T cells, the natural (produced by our body) and artificial (produced in a laboratory) defenders against cancer, by providing them with a mitochondrial super-charge.<\/strong> CAR-T cells are engineered immune cells that are modified to express receptors that specifically target cancer cells. This therapy involves extracting a patient's T cells, enhancing them in a clinical-grade laboratory, and reintroducing them to improve cancer-fighting capabilities.<\/p>\n\n\n\n

\"It's like transforming a standard sedan into a race car. These so-called 'Mito-CAR-T' cells not only achieve greater survival, but are equipped for maximum performance, enabling them to execute a more efficient attack against cancer cells,\" explains Maroun Khoury.<\/p>\n\n\n\n

\n

Published in the scientific journal Journal of Translational Medicine, the study, which was conducted in collaboration with Brazil's National Cancer Institute (INCA), highlights how this innovative mitochondrial transfer technique can enhance natural and engineered T cells, paving the way for advances in cancer immunotherapy. <\/sub><\/p>\n<\/blockquote>\n\n\n\n

\"Basically, we are teaching the old cells new tricks. By increasing their energy production, we are giving these T cells a better chance to survive and overcome their cancer opponents,\" Khoury says.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

This advance addresses one of the main limitations of CAR-T therapy: the short lifespan of the modified T cells in patients. Manipulation during manufacturing can lead to depletion of the cells, reducing their efficacy. However, with optimized survival rates due to mitochondrial enhancements, these modified immune cells could lead to longer-lasting and more effective cancer treatments.<\/p>","protected":false},"excerpt":{"rendered":"

The team led by scientist Maroun Khoury, director of the IMPACT Center of Excellence at University of the Andes, found that transferring mitochondria (the energy-producing organelles of cells) from mesenchymal stem cells to T cells can significantly increase their survival rates and their ability to fight cancer. <\/p>","protected":false},"author":2,"featured_media":4821,"comment_status":"closed","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1284","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"yoast_head":"\nInvestigaci\u00f3n chilena logra mejorar respuesta de c\u00e9lulas contra el c\u00e1ncer - Investiga UANDES<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/investiga.uandes.cl\/en\/in-search-of-the-international-seal\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigaci\u00f3n chilena logra mejorar respuesta de c\u00e9lulas contra el c\u00e1ncer - Investiga UANDES\" \/>\n<meta property=\"og:description\" content=\"El equipo dirigido por el cient\u00edfico Maroun Khoury, director del Centro de excelencia IMPACT de la Universidad de los Andes, descubri\u00f3 que la transferencia de mitocondrias (los org\u00e1nulos productores de energ\u00eda de las c\u00e9lulas) desde c\u00e9lulas madre mesenquimales a c\u00e9lulas T puede aumentar significativamente sus tasas de supervivencia y su capacidad para combatir el c\u00e1ncer.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/investiga.uandes.cl\/en\/in-search-of-the-international-seal\/\" \/>\n<meta property=\"og:site_name\" content=\"Investiga UANDES\" \/>\n<meta property=\"article:published_time\" content=\"2025-02-05T03:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-26T21:58:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/investiga.uandes.cl\/wp-content\/uploads\/2025\/02\/foto-celula-noticia-IMPACT-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Mar\u00eda Ignacia Manr\u00edquez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mar\u00eda Ignacia Manr\u00edquez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/investiga.uandes.cl\/en-busca-del-sello-internacional\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/investiga.uandes.cl\/en-busca-del-sello-internacional\/\"},\"author\":{\"name\":\"Mar\u00eda Ignacia Manr\u00edquez\",\"@id\":\"https:\/\/investiga.uandes.cl\/#\/schema\/person\/4a367eefb9d2846278c9140fd2289574\"},\"headline\":\"Investigaci\u00f3n chilena logra mejorar respuesta de c\u00e9lulas contra el c\u00e1ncer\",\"datePublished\":\"2025-02-05T03:00:00+00:00\",\"dateModified\":\"2025-11-26T21:58:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/investiga.uandes.cl\/en-busca-del-sello-internacional\/\"},\"wordCount\":652,\"publisher\":{\"@id\":\"https:\/\/investiga.uandes.cl\/#organization\"},\"image\":{\"@id\":\"https:\/\/investiga.uandes.cl\/en-busca-del-sello-internacional\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/investiga.uandes.cl\/wp-content\/uploads\/2025\/02\/foto-celula-noticia-IMPACT-1.jpg\",\"articleSection\":[\"Salud\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/investiga.uandes.cl\/en-busca-del-sello-internacional\/\",\"url\":\"https:\/\/investiga.uandes.cl\/en-busca-del-sello-internacional\/\",\"name\":\"Investigaci\u00f3n chilena logra mejorar respuesta de c\u00e9lulas contra el c\u00e1ncer - 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